Dimethylaminoethanol and dimethylethanolamine (DMAE and DMEA), with deanol, is the common name for 2- (dimethylamino) ethanol .
Video Dimethylethanolamine
Chemical and property structure
This compound has a tertiary amine group and a primary alcohol as a functional group. The function of the alcohol, in combination with the amine and its low molecular weight, results in water solubility in the compound, and makes possible ester derivatives; the amine function provides an alkaline character compound, and allows for the salt formulation of the compound.
Security and Poisoning
Although early, it appears that DMAE may aggravate or induce the formation of neural tube defects, as evidenced by in vitro studies in mouse embryonic cells. Under normal conditions, a mouse embryo takes choline and converts it into phosphatidylcholine (PC) as an active substrate. DMAE supplements seem to replace the use of choline when it is present due to higher affinity and competition but fails to be converted to PC due to lack of expression of phosphatidylethanolamine methyltransferase (PeMT) enzyme in embryo. This enzyme is absolutely necessary for conversion of Phosphatidylethanolamine to PC.
Basically, DMAE competitively inhibits Choline absorption during the first few days of neural tube formation (1-10 days after impregnation), but the embryo has not been able to use DMAE as well as mature because of immature CDP-choline metabolic pathways and underexpression of key enzymes.
This mechanism should not occur in adult cells because of the activity of the PeMT enzyme and the metabolic pathways of mature CDP-choline enzymes.
High levels of inhalation exposure are a well-documented cause of the syndrome of reactive airway disorders.
Maps Dimethylethanolamine
Usage
Its characteristics arise from the chemical features as well as from the overall structural similarity to the chemical compounds involved in primary metabolism and neurophysiology.
Biochemical role
According to WebMD:
"Deanol is a chemical that is involved in a series of reactions that make up acetylcholine, a chemical found in the brain and other areas of the body.acetylcholine is a" neurotransmitter "that helps nerve cells communicate.
Deanol is used to treat attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism, and movement disorders called tardive dyskinesia. It is also used to improve memory and mood; improve thinking and intelligence skills; and increase physical energy, oxygen efficiency, athletic performance, and muscle reflexes. It is also used to prevent aging or liver spots, improve the function of red blood cells, and extend life span.
Deanol is applied to the skin to reduce the signs of aging, especially sagging or sagging skin.
Deanol was previously sold by Riker Laboratories as a Deaner prescription medicine. It is prescribed for the management of children with behavioral problems and learning difficulties. Deanol is not a food additive approved in the US, nor is it an orphan drug, as some advertisers suggest. Dimethylaminoethanol may serve as a choline precursor in the liver. In the brain, DMAE is inserted into phospholipids, such as phosphatidyldimethylethanolamine (PDME), which can then be converted, via N -methylation, into phosphatidylcholine. As a component of the neural membrane, PDME can improve fluidity and permeability, and act as an antioxidant.
Topic Usage
DMAE, in the form of facial cream, is being examined to improve skin quality for aging skin when used as a 3% face cream. This shows the benefits of improving the appearance of coarse wrinkles, dark circles under the eyes, nasolabial folds, loose neck skin, and neck firmness and are generally well tolerated.
Especially, DMAE as a facial gel enhances skin firmness.
Neurology
Rheology
DMAE (0.6% in vitro) appears to protect from iron-induced oxidation and subsequent crosslinking of proteins, which are thought to retain membrane fluidity through their anti-oxidative effects, either directly or by preventing the formation of Nitroxyl radicals (binding hydroxyl radicals with hydroxyproline) by a hydroxyl radical that is non-oxidizing to alienate.
Alzheimer Disease
V0191 (DMAE Pyroglutamate) in people aged 55 to 90 years (mean age 72.2) with mild cognitive impairment took 1500mg of supplements daily at breakfast for 24 weeks noting that although there was a tendency for more response to treatment than placebo (defined as more than a 4-point increase on the ADAS-cog scoring scale), no statistically significant improvement or improvement in global appraisal.
Tardive Dyskinesia
DMAE supplementation has been shown in several studies to show a small, though insignificant, positive trend for the symptoms of tardive dyskinesia, but it is usually seen as an ineffective treatment.
Industrial use
Industrial uses include as bulk chemistry in water purification, as good chemical precursors in other pharmaceutical and organic synthesis, and as additives in various applications, including with resins and coatings. There is a growing interest in the use of DMAE as a nutraceutical, and has been tested as a therapeutic agent that may be associated with various cholinergic functions.
DMAE is used in large quantities for water treatment, in the coating industry, and as a preservative for polyurethane and epoxy resins. It is also used in chemical synthesis of dyes, pharmaceuticals, emulsifiers, textile auxiliaries, as additives for paint removal and amino resins, and as an additive for boiler water to provide corrosion resistance. For example, 2-dimethylaminoethyl chloride hydrochloride is synthesized from dimethylaminoethanol, and serves as a widely used intermediate for the manufacture of drugs.
DMAE forms a number of salts with a melting point below the room ionic ionic liquid, (eg N, N -dimethylethanolammonium acetate and N, N -dimethylethanolammonium octanoate), which can be used in the application where alternatives to conventional solvents are required.
Use of neutrophils
Source of the article : Wikipedia
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